About MEAJO | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions to authors | Online submission | Subscribe | Advertise | Contact | Login 
Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
Users Online: 579   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
REVIEW ARTICLE
Year : 2007  |  Volume : 14  |  Issue : 1  |  Page : 24-27

The trachoma ecosystem: A hypothesis on the transmission of trachoma


Rachel Eye Center, Abuja, Nigeria

Correspondence Address:
Olufemi E Babalola
Rachel Eye Center, Plot 897, Gimbiya Street, Garki Phase II, Abuja
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

There is compelling evidence that trachoma-inclusion conjunctivitis (TRIC) agents can and do persist in clinically "healed" subjects, raising the possibility that such persistent cases may constitute reservoirs of infection. The percentage of persistent cases, with antigen detection utilizing polymerase chain reaction, ligase chain reaction, or Giemsa stain techniques, varies from 24% to 53%. The hypothesis put forth in this review is that persistent antigens can cause the endogenous reactivation of clinical disease after being triggered by factors that cannot be clearly elucidated at the present time. Based on the findings of existing studies, it is not evident at this time if single-dose azithromycin will eradicate persistent infection and prevent reactivation through this pathway. Repeat cycles of infection are probably, in large part, caused by this endogenous reactivation, which leads to conjunctival scarring/shrinkage and entropion/trichiasis. The evolution of trachoma from incipient to healed stages, coupled with the infection, reinfection and reactivation cycles, and the interaction of these cycles and stages with environmental factors, compels the postulation of a trachoma ecosystem in which all these factors are integrated.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1872    
    Printed119    
    Emailed1    
    PDF Downloaded116    
    Comments [Add]    

Recommend this journal