|Year : 2007 | Volume
| Issue : 1 | Page : 37-38
Non-hodgkin's lymphoma of the conjunctiva
Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
|Date of Web Publication||11-Nov-2009|
King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462
Source of Support: None, Conflict of Interest: None
| Abstract|| |
The majority of lymphomas of the ocular adnexa are non-Hodgkin's B-cell lymphomas; many of which occur as primary tumors without systemic involvement. A 16-year-old Saudi male was treated at King Khaled Eye Specialist Hospital for primary non-Hodgkin's B-cell lymphoma without evidence of systemic involvement. Over a 4-year period of follow-up, there was no evidence of recurrent conjunctival tumor or systemic lymphoma development.
Keywords: adnexal tumor, B-cell lymphoma, non-Hodgkin′s lymphoma, primary conjunctival tumor, T-cell lymphoma
|How to cite this article:|
Al-Towerki AE. Non-hodgkin's lymphoma of the conjunctiva. Middle East Afr J Ophthalmol 2007;14:37-8
Lymphoid neoplasm may present as primary or secondary tumors of the eyelid, conjunctiva, and orbit. ,, The majority of lymphomas of the ocular adnexa are non-Hodgkin's B-cell lymphomas; many of which occur as primary tumors without systemic involvement. ,, When T-cell lymphomas occur in the orbit, they are usually a secondary manifestation of systemic involvement.
| Case Report|| |
A 16-year-old Saudi boy presented to King Khaled Eye Specialist Hospital, complaining of a painless conjunctival mass in his right eye of at least 3 weeks' duration. He had no history of any medical disorders, and the review of systems was entirely negative. On examination, the visual acuity was 20/20 in both eyes. The ocular examination of both eyes was entirely normal, with the exception of a temporal conjunctival mass measuring 3 x 3 x 7 mm that protruded through the interpalpebral fissure [Figure 1].
An excisional biopsy was performed. Immunohistochemical studies confirmed the diagnosis of non-Hodgkin's B-cell lymphoma. The patient was referred to King Faisal Specialist Hospital and Research Centre for a systemic evaluation; no evidence of systemic disease was detected. Over a 4-year period of follow-up, there was no recurrence of conjunctival lymphoma and no evidence of systemic disease development.
| Discussion|| |
Non-Hodgkin's B-cell lymphoma of the ocular adnexa occurs as a primary tumor that is limited without systemic involvement in 60% to 80% of cases. ,,, In cases where subsequent systemic involvement occurs, it usually takes place within the first 6 months, although it can take place many years later. ,,,
It is imperative that the ophthalmologist perform a diagnostic biopsy on all suspicious lymphoid lesions of the ocular adnexa. Immunohistochemisty can be used to differentiate the lesion from benign lymphoid hyperplasia and B-cell or T-cell lymphoma. ,,,
Once a diagnosis of adnexal lymphoma has been established, the patient must be referred to an oncologist for an evaluation of systemic involvement and staging of the disease. , Investigations include complete blood count (CBC), chest X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) examination of the thorax and abdomen, and bone marrow biopsy. If the systemic evaluation is negative, the primary orbital lymphoma is treated with localized radiotherapy.
Providing patients with long-term follow-up is essential for detecting both the recurrence of orbital disease and the development of systemic lymphoma. In the present case, there has been no evidence of recurrent conjunctival disease or systemic lymphoma development during a 4-year period of follow-up.
| References|| |
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