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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2008  |  Volume : 15  |  Issue : 2  |  Page : 57-60

Intra-operative 5-FU in glaucoma surgery: A Nigerian teaching hospital experience

Ophthalmology Unit, Department of Surgery, College of Health Sciences, Obafemi Awolowo University; Ile-Ife, Osun State, Nigeria

Correspondence Address:
Bernice O Adegbehingbe
Ophthalmology Unit, Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.51993

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Background: 5-Fluorouracil (5-FU) is an anti-metabolite used as an adjunct during the initial stages of a trabeculectomy to prevent excessive post-operative scarring and thus reduce the risk of failure. Objectives: To assess the effects of intra-operative 5-FU in trabeculectomy in Nigerians. Methods : Trabeculectomy with an intra-operative sponge soaked with 5-FU was performed in 49 eyes of 34 patients. The reduction in intra-ocular pressure (IOP), Visual acuity changes and complications were noted. Results: The mean presenting and preoperative IOP was 35.6+/-12.5mmHg and 25.5+/-6.6mmHg respectively. The mean post-operative IOP was 10.0+/- 5.2mmHg on the second post-operative day and 16.5+/7.3mmHg at 3 months. Post-operative complications included ocular hypotony in 4 (25 percent), shallowing of anterior chamber in 3 (18.8 percent), hyphema and cystic bleb in 2 (12.5 percent) each. None had bleb failure. 5 FU appears to reduce the relative risk of failure of trabeculectomy in those undergoing surgery for the first time (relative risk 0.29, 95 percent confidence interval 0.16 to 0.53). Conclusions: The use of 5-FU during trabeculectomy is associated with significant benefit in terms of intraocular pressure lowering beyond 3 months postoperatively. The results of surgery in Nigerian patients compare well with other reported series.

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