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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2009  |  Volume : 16  |  Issue : 2  |  Page : 75-79

Intravitreal bevacizumab (avastin) as an adjuvant treatment in cases of neovascular glaucoma

Ophthalmology Center, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Asaad A Ghanem
Ophthalmology Center, Faculty of Medicine, Mansoura University, Mansoura
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.53865

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Purpose: To evaluate the effect of intravitreal bevacizumab (avastin) injection in cases of neovascular glaucoma. Study Design: Clinical case series. Materials and Methods: Sixteen eyes of 16 patients with rubeosis iridis and secondary glaucoma were administered intravitreal injection of bevacizumab (2.5 mg). The patients were followed for 2 months. Results: We noted partial or complete regression of iris neovascularization 1 week after injection of bevacizumab. Reproliferation of new vessels was detected in 25% of the cases after 2 months. The mean intraocular pressure (IOP) before injection was 28 9.3 mm Hg under topical β-blocker and systemic acetazolamide. One week after injection, the IOP decreased to 21.7 11.5 mm Hg (5 cases without anti-glaucoma drugs, 6 cases with topical β-blocker and 5 cases with both topical β-blocker and systemic acetazolamide). Conclusion: Intravitreal bevacizumab (avastin) injection leads to regression of iris neovascularization with subsequent drop of IOP in eyes with neovascular glaucoma.

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