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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2009  |  Volume : 16  |  Issue : 3  |  Page : 146-150

Vascular risk factors for open angle glaucoma in African eyes

1 Department of Ophthalmology, University of Benin Teaching Hospital, P.M.B 1111, Benin City, Nigeria
2 Department of Ophthalmology, Irrua Specialist Teaching Hospital, P.M.B. 08, Irrua, Edo State, Nigeria

Correspondence Address:
Afekhide E Omoti
Department of Ophthalmology, University of Benin Teaching Hospital, P.M.B 1111, Benin City, Edo State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.56229

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Context : The exact patho physiological mechanizm of optic nerve damage in glaucoma is not fully understood. Aim : To assess the vascular risk factors in open angle glaucoma in African eyes. Settings and Design : Prospective multicenter hospital-based study in Edo State, Nigeria. Materials and Methods : Three hundred and twenty-two glaucoma patients and 184 control subjects were included in the study comprising 200 male glaucoma patients (62.11%) and 122 females (37.89%). A cohort of consecutive patients with a diagnosis of primary open angle glaucoma and age and sex matched control subjects were included in this prospective, cross-sectional, and multicenter hospital-based study conducted during the period January-June 2008. Blood pressure (BP), pulse and intraocular pressure findings were recorded and mean BP, pulse and perfusion pressure for each eye calculated. Statistical Analysis Used : Mean, standard deviations, 95% confidence intervals, Welch's t test, and Fisher's exact test were calculated. Results : The mean IOP in the 644 eyes of the 322 glaucoma patients was 22.65 mmHg (SD plus/minus 11.06). The systolic blood pressure (P < 0.0001), diastolic blood pressure (P < 0.0001), mean arterial blood pressure (P < 0.0001), pulse pressure (P < 0.01), systolic perfusion pressure (P < 0.01) were all significantly higher in glaucoma patients than in control. Conclusions : Higher systolic, diastolic, mean arterial BP and pulse pressure was found in Black African patients with open angle glaucoma.

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