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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2010  |  Volume : 17  |  Issue : 4  |  Page : 387-389

Intravitreal avastin for choroidal neovascularization associated with stargardt-like retinal abnormalities in pseudoxanthoma elasticum

1 Department of Ophthalmology, Policlinico Riuniti di Foggia, University of Foggia, Foggia, Italy; Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris XII, Creteil, France
2 Department of Ophthalmology, Policlinico Riuniti di Foggia, University of Foggia, Foggia, Italy

Correspondence Address:
Giuseppe Querques
Department of Ophthalmology, Policlinico Riuniti di Foggia, University of Foggia, Viale Pinto 1, Foggia, Italy

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.71586

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The aim of the study was to describe a patient with pseudoxanthoma elasticum (PXE), showing Stargardt-like retinal abnormalities, who underwent treatment with intravitreal bevacizumab for subfoveal choroidal neovascularization (CNV) of the right eye (RE). A 57-year-old woman with diagnosis of angioid streaks, retinal flecks, and chorioretinal Stargardt-like atrophy due to PXE was referred to our department for sudden decreased vision in her RE (20/160). Upon a complete ophthalmologic examination, including fluorescein angiography (FA), and optical coherence tomography (OCT), the patient was diagnosed with subfoveal CNV of the RE. Owing to the subfoveal localization of the CNV, the patient was submitted to intravitreal bevacizumab injection. At the 1-month follow-up, visual acuity (VA) improved (20/40), and FA and OCT revealed the CNV closure. Twelve months after the treatment, the patient's VA remained stable with no recurrence of active CNV. On the basis of our findings, a single intravitreal bevacizumab injection seems to induce total regression of CNV complicating PXE, in a patient showing Stargardt-like retinal abnormalities. Further investigations are required to confirm our results.

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