About MEAJO | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions to authors | Online submission | Subscribe | Advertise | Contact | Login 
Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
Users Online: 572   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
OPHTHALMIC GENETICS UPDATE
Year : 2011  |  Volume : 18  |  Issue : 1  |  Page : 2-6

The genetics of keratoconus


Institute of Human Genetics, Polish Academy of Sciences, Poznan, Strzeszynska 32, 60-479 Poznan, Poland

Correspondence Address:
Marzena Gajecka
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Strzeszynska 32, 60-479 Poznan
Poland
Login to access the Email id

Source of Support: Support by Ministry of Eduction and Science, Poland, Grant NN 402097837, Conflict of Interest: None


DOI: 10.4103/0974-9233.75876

Rights and Permissions

Keratoconus (KTCN) is non-inflammatory thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive error, and decreased vision. Keratoconus is a complex condition of multifactorial etiology. Both genetic and environmental factors are associated with KTCN. Evidence of genetic etiology includes familial inheritance, discordance between dizygotic twins, and association with other known genetic disorders. Several loci responsible for a familial form of KTCN have been mapped; however, no mutations in any genes have been identified for any of these loci. This article focuses on the genetic aspects. In addition, bioinformatics methods applied in KTCN gene identification process are discussed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5936    
    Printed285    
    Emailed2    
    PDF Downloaded412    
    Comments [Add]    
    Cited by others 25    

Recommend this journal