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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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REVIEW ARTICLE
Year : 2012  |  Volume : 19  |  Issue : 1  |  Page : 70-74

Role of inflammation in the pathogenesis of diabetic retinopathy


Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Ahmed M Abu El-Asrar
Department of Ophthalmology, King Abdulaziz University Hospital, Old Airport Road, P.O. Box 245, Riyadh 11411
Saudi Arabia
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Source of Support: Medical Research Chair funded by Dr. Nasser Al-Rasheed, Conflict of Interest: None


DOI: 10.4103/0974-9233.92118

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Diabetic retinopathy (DR) remains a major cause of worldwide preventable blindness. The microvasculature of the retina responds to hyperglycemia through a number of biochemical changes, including activation of protein kinase C, increased advanced glycation end products formation, polyol pathway, and oxidative stress, and activation of the renin angiotensin system (RAS). There is an accumulating body of evidence that inflammation plays a prominent role in the pathogenesis of DR.


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