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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2012  |  Volume : 19  |  Issue : 4  |  Page : 361-363

Isolates and antibiotic resistance of culture-proven endophthalmitis cases presented to a referral center in Tehran

1 Eye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Ophthalmology, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Khalil Ghasemi Falavarjani
Assistant Professor of Ophthalmology, Eye Research Center, Rassoul Akram Hospital, Sattarkhan-Niayesh Street, Tehran 14455-364
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.102740

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Purpose: To evaluate the spectrum of organisms causing endophthalmitis and their resistance pattern to standard antimicrobial agents. Materials and Methods: Medical records of culture positive eyes treated at Rassoul Akram Hospital for endophthalmitis during the past 5 years were reviewed. Specimens were obtained during pars plana vitrectomy or vitreous tap. Results: Sixty-five isolates including 36 (55.4%) gram-positive organisms, 28 gram-negative organisms (43.1%), and 1 (1.5%) fungus were studied. The most common organism identified was Coagulase-negative staphylococcus in 16 eyes (24.6%). Among the antibiotics available for intravitreal injection, the least antibiotic resistance was for vancomycin in gram-positive organisms and amikacin and ceftazidime in gram-negative isolates. Conclusions: Gram-positive isolates were the most prevalent organisms; however, a high isolation rate for gram-negative organisms was obtained. Considering that no single antibiotic provides coverage for all of the organisms, a combination therapy using vancomycin/amikacin or vancomycin/ceftazidime seems to be useful as the initial empiric treatment of suspected bacterial endophthalmitis.

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