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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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CASE REPORT
Year : 2012  |  Volume : 19  |  Issue : 4  |  Page : 432-435

Long-term management of orbital and systemic reactive lymphoid hyperplasia with rituximab


1 Department of Ophthalmology, University of California-San Francisco, San Francisco, California, USA
2 Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
3 Massachusetts Eye and Ear Infirmary, Harvard University School of Medicine, Boston, Massachusetts, USA

Correspondence Address:
Timothy J McCulley
The Wilmer Eye Institute, Johns Hopkins School of Medicine, 600 North Wolfe Street, Wilmer 110, Baltimore, MD, USA

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-9233.102770

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Rituximab, a monoclonal antibody to the B cell marker CD20, is becoming increasingly popular in the treatment of various orbital disorders. In this university-based interventional case series, we describe two patients with bilateral orbital and extra-orbital reactive lymphoid hyperplasia (RLH) treated with rituximab. Initially both had favorable responses; but roughly a year later recurrent disease necessitated maintenance therapy in both cases. Both again responded to additional courses of rituximab. Although recalcitrant disease may persist after treatment, rituxmab may play a role in the management of RLH with widespread involvement.


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