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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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SYMPOSIUM - OCULAR THERAPEUTICS OF THE FUTURE
Year : 2013  |  Volume : 20  |  Issue : 1  |  Page : 11-25

Strategies for local gene therapy of corneal allograft rejection


1 The Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
2 The Wilmer Eye Institute, Baltimore, Maryland, USA, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Samuel C Yiu
The Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, 21287, Maryland
Saudi Arabia
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Source of Support: NEI core grant EY03040 and an unrestricted grant from Research to Prevent Blindness. Pho Nguyen is supported by the Heed Ophthalmic Foundation and the Fletcher Jones Foundation,, Conflict of Interest: None


DOI: 10.4103/0974-9233.106382

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Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.


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