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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2013  |  Volume : 20  |  Issue : 1  |  Page : 5-10

Presentation, diagnosis and management of limbal stem cell deficiency

1 Aditya Jyot Eye Hospital, Mumbai, India
2 Tehran University of Medical Sciences, Tehran, Iran
3 Jules Stein Eye Institute, University of California, Los Angeles, California, USA

Correspondence Address:
Sophie X Deng
Cornea and Uveitis Division, Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095
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Source of Support: An R01 grant (EY021797) from the National Eye Institute and an Early Translational Grant (TR2-01768) from the California Institute for Regenerative Medicine (SXD)., Conflict of Interest: None

DOI: 10.4103/0974-9233.106381

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The human corneal surface epithelium is continuously repopulated by the limbal stem cells (LSCs). Limbal Stem Cell Deficiency (LSCD) can lead to corneal opacity and vascularization, with consequent visual impairment or blindness. Many acquired and congenital diseases can lead to LCSD by direct injury to the LSCs, destruction of LSC niche, or both. Based on the severity of the disease, LSCD can present with various symptoms and signs. Although LSCD can be detected clinically, laboratory tests are necessary to confirm the diagnosis and monitor the disease progression. This article concisely reviews the clinical presentation, techniques for diagnosis and management of LSCD.

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