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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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CASE REPORT
Year : 2013  |  Volume : 20  |  Issue : 1  |  Page : 77-79

In vivo confocal microscopy in chloroquine-induced keratopathy


Department of Oto-Neuro-Ophthalmological Surgical Sciences, Eye Clinic, University of Florence, Policlinic of Careggi, Viale Morgagni 85, 50134, Florence, Italy

Correspondence Address:
Iacopo Paladini
Department of Oto-Neuro-Ophthalmological Surgical Sciences - Eye Clinic, Viale GB Morgagni 85, 50134 Florence
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-9233.106397

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In vivo confocal microscopy is becoming a mandatory examination to study corneal abnormalities such as drug deposits in systemic disease. A female diagnosed with fibromyalgia on systemic chloroquine for 9 months presented for an ophthalmic examination. Confocal microscopy was performed using the Confoscan 4 (Nidek Co. Ltd., Gamagori, Japan) and multiple highly reflective deposits in the epithelial basal cells were found, that were consistent with choloquine. Deposits were also present in the wing cell layer. In the anterior stroma these deposits were rare. Atypically shaped and branched nerves were also present in the anterior stroma. Corneal deposits of chloroquine can be evaluated by confocal microscopy. Confocal microscopy provides information on corneal metabolism and physiology. Chloroquine keratopathy can affect the anterior stroma in addition to the epithelium.


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