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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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DIABETIC RETINOPATHY UPDATE
Year : 2013  |  Volume : 20  |  Issue : 4  |  Page : 309-314

Should we start all patients with diabetic retinopathy on fenofibrates?


1 Department of Ophthalmology, Christian Medical College, Ludhiana, Punjab, India
2 Department of Medicine, Christian Medical College, Ludhiana, Punjab, India

Correspondence Address:
Jacob Koshy
Department of Ophthalmology, Christian Medical College, Ludhiana - 141 008, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-9233.120012

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There remains a need for strategies that are effective in preventing diabetic retinopathy (DR) or slowing down its progression, which is safe, well-tolerated, and more effective, have a lower risk profile, easy to perform, have more predictable results with less morbidity than the current regimens. Physicians caring for diabetic patients not only need to maximize glycemic control, but also closely monitor and treat other systemic conditions. The consistency of clinical data from the fenofibrate studies showed consistent beneficial effects with fenofibrate in slowing the progression of DR. They demonstrated significant benefit on micro-vascular (i.e., retinopathy and nephropathy) outcome, possibly independent of lipid levels. Can we combine the effectiveness of the current standard procedures with the prevention and slowing down of progression of DR that fenofibrates can offer? Knowledge of the primary mode of action of fenofibrate will be useful for both physicians and patients in determining how best to use this drug as an adjunct in the management of DR and ultimately facilitating the translation of clinical trial data to clinical practice.


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