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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2014  |  Volume : 21  |  Issue : 1  |  Page : 32-39

Gradient refractive index optics IOL: Theoretical background and clinical results

S. Fyodorov Eye Mucrosurgery Complex State Institution, Beskudnikovsky Blvd, Moscow, Russian Federation

Correspondence Address:
Boris Malyugin
S. Fyodorov Eye Mucrosurgery Complex State Institution, Beskudnikovsky Blvd 59A, Moscow - 127 486
Russian Federation
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.124086

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Purpose: To present the theoretical optical background and clinical results of a new multifocal intraocular lens (MIOL) concept-gradient refractive index optics (Gradiol). Patients and Methods: Original mathematical modeling software was used to calculate optimal construction of the MIOL optic constructed from two polymer materials with different refractive indices. Gradiol lenses were manufactured from hydrophobic acrylic utilizing original step-by-step polymerization technology with the final power difference of of 3.5 D between optic components. Non-comparative prospective clinical study included 26 patients (29 eyes) who were candidates for MIOL implantation. All surgeries were performed at the S. Fyodorov Eye Microsurgery Complex State Institution, Moscow, Russia. After implantation of the Gradiol lenses, the postoperative evaluations included distance (best corrected visual acuity (BCVA)) and near visual acuity (NVA), contrast sensitivity (CS), and amplitude of pseudoaccommodation. Subjective patient's satisfaction was assessed using a questionnaire (VF-14). Results: The mean age of the patients was 62.5 ± 5.7 years (range 27-82 years). All surgical procedures were uneventful. At 6 months postoperatively, the mean uncorrected distance VA was 0.73 ± 0.18, mean uncorrected near VA was 0.57 ± 0.19, mean corrected distance VA was 0.89 ± 0.15, mean corrected near VA was 0.84 ± 0.07, and amplitude of pseudoaccommodation was 4.75 ± 0.5 D. Eighty-six percent of patients were spectacle independent for daily activities and reading. Optical disturbances that were functionally significant were reported by 10.7% of patients postoperatively. Conclusion: The clinical outcomes of this study confirmed the theoretical calculations of constructing MIOL optics from materials with different refractive indices.

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