| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 22
| Issue : 2 | Page : 186-191 |
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Quantitative analysis of segmented fluorescein angiography images for the follow-up of choroidal neovascular membrane
Sambuddha Ghosh1, Pampa Haldar2, Prashanth Ravindran3, Jyotirmoy Chatterjee4, Sandeep V Paranjape4, Gautam Bhaduri5
1 Department of Ophthalmology, North Bengal Medical College, West Bengal, India
2 Department of Ophthalmology, RG Kar Medical College, Kolkata, West Bengal, India
3 Department of Electrical Engineering, IIT, New Delhi, India
4 Department of School of Medical Science and Technology, IIT, Kharagpore, West Bengal, India
5 Department of Ophthalmology, RIO, Kolkata, West Bengal, India
Correspondence Address:
Sambuddha Ghosh
BB41/8, Salt Lake City, Kolkata - 700 064
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-9233.151869
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Purpose: The aim of this study was to evaluate choroidal neovascular (CNV) lesions with fluorescein angiography (FA) and to identify quantitative parameters and correlate these parameters to treatment outcomes.
Subjects and Methods: This institution based cross-sectional study evaluated 30 eyes with active sub-foveal predominantly classic CNV treated with bevacizumab. Pre- and post-injection segmented FA images were analyzed. Lesion area and CNV lesion were manually delineated. Outcome measure was the change 1-month after each injection in different intensity values (0-255 divided in eight regions A [lowest intensity] to H [highest intensity] on a linear scale) in lesion area, perimeter, greatest linear dimension (GLD), area, visual acuity (VA) and central macular thickness (CMT).
Results: At month 3, statistically significant changes from baseline occurred in VA, CMT, lesion area, GLD and perimeter (P < 0.05 all comparisons). Change in CMT from baseline to 3 months postinjection was correlated with change in VA (P = 0.009, r = 0.469) and intensity regions B (P = 0.001, r = −0.565), D (P = 0.001, r = 0.560), E (P = 0.035, r = 0.386). At month 3, change in intensity values 0-63 (A + B) was negatively correlated with CMT (P = 0.001, r = −0.575) and lesion area (P = 0.019, r = −0.427); change in intensity values 64-223 (C-G) was positively correlated with CMT (P = 0.000, r = 0.636) and lesion area (P = 0.002, r = 0.551).
Conclusions: Decrease in area, GLD, perimeter and area with intensity ≥ 64 on segmented FA were associated with a favorable outcome of treatment. These parameters may be useful adjuncts to existing evaluation techniques during follow-up of CNV.
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