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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2016  |  Volume : 23  |  Issue : 2  |  Page : 212-214

Comparison of serum apolipoproteins and traditional lipids in eyes with diabetic retinopathy in Indian population: A case series

1 Department of Ophthalmology, S.N Medical College, Agra, Uttar Pradesh, India
2 Department of Pathology, S.N Medical College, Agra, Uttar Pradesh, India

Correspondence Address:
Rachit Agrawal
Room No. 186, SBH, S.N Medical College, Agra - 282 002, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-9233.171752

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Purpose: To review the associations of serum lipoproteins and apolipoproteins with diabetic retinopathy (DR). Materials and Methods: This was a cross-sectional study of patients of DR. DR was graded according to modified Airlie House Classification system. Traditional serum lipids (total, low-density lipoprotein [LDL], and high-density lipoprotein [HDL] cholesterol and triglycerides [TGs]), apolipoprotein AI (apoAI), apolipoprotein B (apoB), and apoB-to-apoAI ratios were assessed. The analysis of variance test was applied. P < 0.05 was considered statistically significant, and P < 0.001 was considered highly significant. Results: Twenty-four patients with DR were evaluated. Serum apoAI was statistically significantly associated with a reduced likelihood of having more severe DR levels (P < 0.001). Increasing levels of apoB (P < 0.001) and apoB-to-apoAI ratio (P < 0.001) were statistically significantly associated with increasing DR severity levels. The association of total (P > 0.05) and LDL cholesterol (P > 0.05) with severity of DR was not statistically significant. HDL cholesterol levels were inversely associated with the severity of DR (P < 0.05). TGs were also statistically significantly associated with the severity of DR (P < 0.05). Conclusion: Serum apolipoprotein levels may be stronger biomarkers of DR than traditional lipids.

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