|LETTER TO THE EDITOR
|Year : 2017 | Volume
| Issue : 4 | Page : 222
Demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
|Date of Web Publication||12-Jan-2018|
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P.O. Box. 55302, Baghdad Post Office, Baghdad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Al-Mendalawi MD. Demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran. Middle East Afr J Ophthalmol 2017;24:222
|How to cite this URL:|
Al-Mendalawi MD. Demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran. Middle East Afr J Ophthalmol [serial online] 2017 [cited 2020 Aug 12];24:222. Available from: http://www.meajo.org/text.asp?2017/24/4/222/223110
I read with interest the study by Rahimi et al. on the demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran. The authors mentioned that noninfectious uveitis was detected in 81.5% of the studied patients compared to 18.5% for infectious uveitis. Among the infectious category, there were four patients with toxocariasis, four patients with toxoplasmosis, and one patient with herpes simplex virus infection. Interestingly, no case of human immunodeficiency virus (HIV)-associated uveitis was reported. It is obvious that HIV infection is one of the twenty- first century's biggest global challenges to humankind with wide manifestations affecting all organs of our body, including eyes. It has been reported that there was a 52%–100% lifetime accumulative risk of HIV-positive patients developing various ocular problems. Seventy-seven percent of patients with ocular manifestations of HIV infection have been noticed to have CD4 counts <200 cells/μL. In an interesting Thailand study, intraocular HIV-1 RNA was detected in 32% of HIV-positive patients with uveitis. Intraocular HIV-1 RNA loads were associated with high-HIV-1 RNA plasma loads (P < 0.001) and not being on highly active antiretroviral therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were found to be higher in patients with the absence of retinal lesions (P = 0.008). In 7% of HIV-positive patients, the HIV load in the eye largely exceeded that of plasma. Although no recent data on the exact prevalence of HIV infection in the pediatric population are yet present in Iran, the available data pointed out that the overall HIV rates in Iran have generally increased by 80% per year for the past decade. It was not clearly evident in the methodology of Rahimi et al.'s study that HIV infection was considered in the studied cohort through appropriate workp of CD4 count and viral overload measurements. Hence, I presume that the actual rate of pediatric HIV-associated uveitis might be underestimated.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Rahimi M, Oustad M, Ashrafi A. Demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran. Middle East Afr J Ophthalmol 2016;23:237-40.
] [Full text]
Mowatt L. Ophthalmic manifestations of HIV in the highly active anti-retroviral therapy era. West Indian Med J 2013;62:305-12.
Pathanapitoon K, Riemens A, Kongyai N, Sirirungsi W, Leechanachai P, Ausayakhun S, et al.
Intraocular and plasma HIV-1 RNA loads and HIV uveitis. AIDS 2011;25:81-6.
HIV in Iran. Lancet 2013;382:1958.