Outcome analysis of visual acuity and side effect after ruthenium-106 plaque brachytherapy for medium-sized choroidal melanoma
Tahra AlMahmoud1, Sean Quinlan-Davidson2, Gregory R Pond3, Jean Deschênes4
1 Department of Surgery, Collage of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE; Department of Ophthalmology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
2 Department of Radiation Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada
3 Department of Oncology, Henderson Research Unit, McMaster University, Hamilton, Ontario, Canada
4 Department of Ophthalmology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Dr. Tahra AlMahmoud
College of Medicine and Health Sciences, United Arab Emirates University, P. O. Box: 17666, Al Ain, United Arab Emirates
Source of Support: None, Conflict of Interest: None
PURPOSE: The purpose of this study is to report on treatment outcomes for medium-sized choroidal melanoma treated with Ruthenium-106 (Ru-106) plaque brachytherapy.
METHODS: A retrospective case series of 28 patients received Ru-106 brachytherapy treatment for choroidal melanoma. The prescribed tumor dose was 85 Gy to a depth of 5 mm.
RESULTS: Median follow-up was 31.2 months. At 12 and 24-month postirradiation, the best corrected visual acuity ≥20/70 (LogMar ≥−0.54) was 53.8% and 64.2%, respectively. Median time to tumor regression was estimated to be 10 months (95% CI = 9–18 months), with 100% of response rate by 32 months. Radiation-induced side effects were limited, and there were no postradiation enucleations.
CONCLUSIONS: The majority of patients maintained good visual acuity, with no enucleations and minimal side effects. In this cohort, the Ru-106 plaque brachytherapy proved to be an efficacious and safe treatment option for patients with medium-sized choroidal melanomas with a maximal tumor height of 5 mm.