|Year : 2019 | Volume
| Issue : 3 | Page : 158-162
Visual outcome of preterm infants screened in a tertiary care hospital
Anuja Sathar1, Shanavas Abbas2, Zinia T Nujum3, Jasmin L Benson1, Girijadevi P Sreedevi1, Sobha K Saraswathyamma2
1 Regional Institute of Ophthalmology, Government Medical College Hospital, Thiruvananthapuram, Kerala, India
2 Department of Pediatrics, Government Medical College Hospital, Thiruvananthapuram, Kerala, India
3 Department of Community Medicine, Government Medical College Hospital, Thiruvananthapuram, Kerala, India
|Date of Submission||19-Feb-2017|
|Date of Decision||22-Aug-2019|
|Date of Acceptance||12-Sep-2019|
|Date of Web Publication||30-Sep-2019|
Dr. Anuja Sathar
Regional Institute of Ophthalmology, Government Medical College, Thiruvananthapuram, Kerala
Source of Support: None, Conflict of Interest: None
| Abstract|| |
OBJECTIVE: The aim of this study is to assess the incidence of retinopathy of prematurity (ROP) in preterm infants and to compare the visual outcomes in babies with and without ROP.
AND METHODS: A consecutive cohort of 812 preterm babies were recruited with gestational age ≤32 weeks and or birth weight ≤1500 g. The outcome was assessed at the end of 15 months by determining fixation behavior, cycloplegic refraction, and vision by Cardiff cards. Incidence of visual outcomes with 95% confidence limits and relative risks were estimated. Chi-squared test and t-test were used as tests of significance.
RESULTS: The incidence of ROP was 25%. The incidence of myopia, hypermetropia, astigmatism, and strabismus were 15.8% (14.3–17.3), 6% (5.1–7.1), 55.6% (53.6–57.7), and 1.8% (1.4%–2.5%), respectively, in the cohort. The most common refractive error in terms of spherical equivalence was myopia (19.8% in ROP and 14.4% in non-ROP group). The mean visual acuity measured by Cardiff Acuity cards was 0.282 and 0.27 logarithm of the minimum angle of resolution units (right eye) and 0.293 and 0.277 (left eye) in patients with and without ROP, respectively. Strabismus was present in 5% of ROP group and 0.8% of non-ROP group babies. Babies with ROP had six times (risk ratio-6.02; 95% confidence interval 2.8–12.8) higher chance of developing strabismus than those without ROP.
CONCLUSIONS: Ophthalmological morbidities in premature infants such as refractive errors and strabismus are high in addition to complications like ROP. The incidence of these conditions is more in infants with ROP when compared to non-ROP group.
Keywords: Functional outcome, preterms, refractive error, retinopathy of prematurity, visual acuity
|How to cite this article:|
Sathar A, Abbas S, Nujum ZT, Benson JL, Sreedevi GP, Saraswathyamma SK. Visual outcome of preterm infants screened in a tertiary care hospital. Middle East Afr J Ophthalmol 2019;26:158-62
|How to cite this URL:|
Sathar A, Abbas S, Nujum ZT, Benson JL, Sreedevi GP, Saraswathyamma SK. Visual outcome of preterm infants screened in a tertiary care hospital. Middle East Afr J Ophthalmol [serial online] 2019 [cited 2019 Dec 15];26:158-62. Available from: http://www.meajo.org/text.asp?2019/26/3/158/268251
| Introduction|| |
Vision-related problems are one of the major sequelae of prematurity. In middle-income countries, high rates of premature birth and increasing resuscitation of premature infants, often with suboptimal standards of care, have resulted in the third epidemic of retinopathy of prematurity (ROP). The visual compromise from increased incidence of refractive errors, strabismus, and cerebral vision impairment has significant impact on visual functions and development such as psychological and educational aspects.
The primary objective of the study was to assess the incidence of ROP in preterm infants. The secondary objective was to compare the visual outcomes (refractive errors, functional outcomes, and visual acuity) in infants with and without ROP.
| Materials and Methods|| |
A hospital-based prospective screening study was done for 24 months during the period April 2013–April 2015. A cohort of 812 consecutive premature babies ≤1.5 kg and or ≤32 weeks of gestational age were included in the study. None of these babies were excluded for any reason since we were interested in knowing the visual outcomes of preterm infants. The eyes of these preterm infants were screened after dilating with 1% tropicamide and 2.5% phenylephrine eye drops applied 10 min apart 1 h before the examination. Classification of ROP was done according to the International Classification of ROP  guidelines. These preterm infants were followed up periodically until maturation of retina or regression of the disease.
For those babies with ROP depending on the severity of the disease, observation was done for mild cases and treatment with diode laser (810 nm) photocoagulation was given for severe disease. Interventions and follow-up examinations were done according to the Early Treatment of ROP (ETROP) guidelines. All these babies were followed up until 15 months of age and visual outcomes analyzed in 1596 eyes of 798 babies.
Visual outcomes were assessed by
- Cycloplegic refraction done at 15 months of age. For this, the pupils were dilated using atropine 1% eye ointment applied twice daily for 3 days prior to refraction. In our study, refractive errors have been classified in terms of spherical equivalence calculated from the retinoscopy readings. A conversion to spherical equivalent (SE) was made, as the algebraic sum of the value of the sphere and half the cylindrical value, for statistical purposes.
Myopia is classified into three categories, according to the value of the SE, as low myopia 0–−3 diopters, moderate myopia − 3–−6 diopters, and high myopia >−6 diopters. Emmetropia is classified as 0–4 diopters and hypermetropia as >4 diopters. Astigmatism is defined as cylindrical correction of ≥1 D  Astigmatism is calculated in plus cylinder form and classified as with-the-rule (WTR) 75°–105°, against-the-rule (ATR) 0°–15° and 165°–180°, and oblique (OBL) 16°–74° and 106°–164°.
- Presence of strabismus or nystagmus
Strabismus was detected using the Hirschberg test and cover tests.
- Visual acuity testing by Cardiff visual acuity cards. Monocular noncycloplegic visual acuity was measured in each eye in sitting position at a test distance of 1 m at 15 months of age. Babies requiring refractive correction were given glasses. It uses a target design of vanishing optotypes and employs the principle of preferential looking.
The targets are drawn with a white band bordered by two black bands, each of half-width of the white band, all on a neutral gray background, thus the average luminance of the target is equal to that of the grey background. In the Cardiff test, each target is positioned either in the top half or in the bottom half of the card. The Cardiff test includes three cards at each acuity level, although only two are usually presented. Beginning with the widest target (lowest acuity), the three cards are shuffled, and the first card is presented at the child's eye level. The calibration for the cards presents acuity levels for the two testing distances, in both equivalent Snellen acuity and logarithm of the minimum angle of resolution (LogMAR).
Visual outcome in terms of ROP was measured as the incidence of ROP with its 95% confidence intervals (CI). All qualitative variables are summarized in percentages and quantitative variables as means with standard deviation. Refractive errors and functional outcome (strabismus) in infants with and without ROP were compared using Chi-squared test, since they were qualitative variables and expressed in %. The comparison of mean visual acuity in the two groups was done using Student's t-test, since it was a quantitative variable. Incidence of refractive errors, strabismus, and visual acuity in infants with ROP and without ROP was also compared using relative risks and its 95% CI.
Ethical clearance was obtained from the Institutional Ethics Committee and informed consent of parents was obtained. The study conforms to the guidelines of the Declaration of Helsinki. Statistical analysis was performed using SPSS version 22 (Statistical Package for the Social Sciences, IBM Corp., New York, NY, USA).
| Results|| |
The incidence of ROP in our study is 25% (95% CI 22.49%–27.52%). Among the 812 preterm babies enrolled in the study, the outcome was assessed in 1596 eyes of 798 babies, of which 199 babies had ROP. Fourteen cases (1.7%) were not included in the follow-up analysis, as eight of them lost their lives, of which four were with ROP. Six babies were lost to follow-up.
In our study, the severity of ROP shows, 209 eyes in Stage 1 ROP, 75 eyes in Stage 2 disease, 98 eyes in Stage 3 disease, and 16 eyes had aggressive posterior ROP (APROP). Laser photocoagulation was done in 56 babies with severe as well as Type 1 prethreshold ROP which accounted for 27.5%. More than one sitting of laser was required in five cases. Additional intravitreal antivascular endothelial growth factor therapy was given in one patient with severe APROP which showed prolonged activity. All babies with ROP had bilateral involvement. All types of ROP regressed at 6 months of follow-up.
The significant refractive error present on follow-up at 15 months of age in cases with and without ROP was myopia (19.8% in ROP cases and 14.4% without ROP). This difference was statistically significant (P = 0.01), and the relative risk was 1.37 (CI 1.08–1.99) [Table 1]. Among myopic babies, the incidence of high myopia was 12%. Hypermetropia was present in 8.5% of ROP and 5.2% of non-ROP patients (P = 0.02). Anisometropia of >1 diopter was present in 26% babies.
|Table 1: Analysis of refractive and functional outcome in the eyes of babies with and without retinopathy of prematurity|
Click here to view
Astigmatism was present in around 60.6% of eyes with ROP and 54% cases without ROP (P = 0.02). WTR astigmatism was present in 86% cases, ATR in 12%, and OBL astigmatism in 2% infants. The relative risks of all the refractive visual outcomes studied were significantly higher among babies with ROP compared to those without ROP [Table 1].
Regarding functional outcome, visual behavior by fixing and following light was good in all except three babies who had neurological sequelae and visual inattention due to global developmental delay. Functional outcome in terms of visual behavior was studied [Table 1]. Strabismus was present in 5% of ROP group and 0.8% of non-ROP group babies. Strabismus with associated nystagmus was present in one baby. All babies with strabismus had esotropia. Babies with ROP had six times higher chance of developing strabismus than babies without ROP (risk ratio = 6.02 and CI = 2.84–12.75).
Visual acuity was assessed by Cardiff Acuity Test (CAT) which showed good outcome with Snellen equivalent >6/12 in most patients of the cohort [Table 2]. The mean visual acuity measured by Cardiff Acuity cards was 0.282 and 0.27 logMAR units (right eye) and 0.293 and 0.277 logMAR (left eye) in patients with and without ROP, respectively. Summary statistics of visual acuities in logMAR units is shown in [Table 3]. Comparison of mean visual acuity in logMar between babies with and without ROP, excluding those with visual inattention due to neurological cause (logMAR 1) shows slightly lower visual acuity in babies with ROP which is not significant [Table 4].
|Table 2: Visual acuity in logarithm of the minimum angle of resolution units|
Click here to view
|Table 3: Summary statistics of visual acuity in babies with and without retinopathy of prematurity|
Click here to view
|Table 4: Difference in mean visual acuity between babies with and without retinopathy of prematurity|
Click here to view
| Discussion|| |
The incidence of ROP in our study is 25%, in concordance with various studies, in which the reported incidence ranges from 19% to 26% among the low-birth-weight babies.,,
Myopia was the predominant refractive error in the cohort comprising around 15.8% of cases when assessed at 15 months of age. Low birth weight and prematurity contribute to myopia in infancy. In addition to this, the incidence of myopia rises in infants with ROP as compared to those without ROP of same birth weight. The ETROP  study reported that 80% of threshold ROP infants and 65% of treated high-risk prethreshold infants had myopia. Studies show that laser treatment also contributes to myopia in ROP infants. The incidence of myopia in our study is less compared to these studies , and comparable to study by Katoch et al.
The increased incidence of myopia in ROP is distinct from that of full-term patients and is mostly associated with lens thickness with lesser contribution from corneal steepness and axial length. Eyes of premature infants have shorter axial lengths, shallower anterior chambers, and more highly curved corneas than eyes of full-term infants. These differences become more significant as the severity of ROP increases. Furthermore, it has been shown that spontaneously regressed ROP has lesser myopia compared to treatment groups. The risk factors for myopia are a greater number of clock hours of ROP, greater number of laser spots, and a longer time to regression of ROP similar to our study.
According to study by Davitt et al., astigmatism was not influenced by zone of acute-phase ROP, presence of plus disease, or retinal residua similar to our study. WTR astigmatism was common in most of the preterms according to several studies.,, The incidence of anisometropia more than 1 D SE was less compared to the study by Varughese et al. The incidence of the same in their study was 31%.
Testing visual acuity in infants is difficult because of their short attention span and restlessness. The CAT overcomes the symbolic demands and is a test of choice for young children. There are only few Indian studies involving visual acuity estimation with Cardiff cards. Cardiff acuity cards are enjoyable and child-friendly, though they are not as precise and tend to overestimate vision compared to Teller acuity cards. As with other studies, the assessment of visual acuity with the CAT was seen to underdiagnose reduced acuity caused by refractive errors.
Strabismus was present in thirty patients in the study, of which twenty were in the ROP group. All patients with strabismus had esotropia. The rate of strabismus was lower than that of ETROP  study which had 22.9% and also in many other studies which had higher incidence. Infants with ROP show significant variability in the presence versus absence of strabismus in the 1st year of life; thus, conservative management is recommended initially.
| Conclusions|| |
Incidence of ROP is 25% or one-fourth of preterm infants have ROP. There is no statistically significant difference in visual acuity between those with ROP and those without ROP. Vision-related morbidities were higher in babies with ROP compared to those without ROP. The study helps in reaching a normative data of visual outcome in preterm babies with and without ROP, from this part of the country.
Financial support and sponsorship
Kerala State Council for Science, Technology and Environment (KSCSTE), Thiruvananthapuram, Kerala, India.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Zin A, Gole GA. Retinopathy of prematurity-incidence today. Clin Perinatol 2013;40:185-200.
O'Connor AR, Wilson CM, Fielder AR. Ophthalmological problems associated with preterm birth. Eye (Lond) 2007;21:1254-60.
International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 2005;123:991-9.
Early Treatment FOR Retinopathy Of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: Results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003;121:1684-94.
Cook A, White S, Batterbury M, Clark D. Ocular growth and refractive error development in premature infants with or without retinopathy of prematurity. Invest Ophthalmol Vis Sci 2008;49:5199-207.
Katoch D, Sanghi G, Dogra MR, Beke N, Gupta A. Structural sequelae and refractive outcome 1 year after laser treatment for type 1 prethreshold retinopathy of prematurity in Asian Indian eyes. Indian J Ophthalmol 2011;59:423-6.
] [Full text]
Shah PK, Ramakrishnan M, Sadat B, Bachu S, Narendran V, Kalpana N. Long term refractive and structural outcome following laser treatment for zone 1 aggressive posterior retinopathy of prematurity. Oman J Ophthalmol 2014;7:116-9.
] [Full text]
Adoh TO, Woodhouse JM. The Cardiff acuity test used for measuring visual acuity development in toddlers. Vision Res1994;14:1063-6.
Abdel HA, Mohamed GB, Othman MF. Retinopathy of prematurity: A study of incidence and risk factors in NICU of al-minya university hospital in Egypt. J Clin Neonatol 2012;1:76-81.
Hakeem AH, Mohamed GB, Othman MF. Retinopathy of prematurity: A study of prevalence and risk factors. Middle East Afr J Ophthalmol 2012;19:289-94.
] [Full text]
Chaudhari S, Patwardhan V, Vaidya U, Kadam S, Kamat A. Retinopathy of prematurity in a tertiary care center incidence, risk factors and outcome. Indian Pediatr 2009;46:219-24.
Dhawan A, Dogra M, Vinekar A, Gupta A, Dutta S. Structural sequelae and refractive outcome after successful laser treatment for threshold retinopathy of prematurity. J Pediatr Ophthalmol Strabismus 2008;45:356-61.
Sahni J, Subhedar NV, Clark D. Treated threshold stage 3 versus spontaneously regressed Indian eyes. Indian J Ophthalmol 2011;59:423-6.
Davitt BV, Dobson V, Quinn GE, Hardy RJ, Tung B, Good WV. Early treatment for retinopathy of prematurity cooperative group. Astigmatism in the early treatment of Indian eyes. Indian J Ophthalmol 2011;59:423-6.
Varughese S, Varghese RM, Gupta N, Ojha R, Sreenivas V, Puliyel JM. Refractive error at birth and its relation to gestational age. Curr Eye Res 2005;30:423-8.
Howard C, Firth AY. Is the Cardiff acuity test effective in detecting refractive errors in children? Optom Vis Sci 2006;83:577-81.
Mody KH, Kothari MT, Sil A, Doshi P, Walinjkar JA, Chatterjee D. Comparison of lea gratings with Cardiff acuity cards for vision testing of preverbal children. Indian J Ophthalmol 2012;60:541-3.
] [Full text]
Sharma P, Bairagi D, Sachdeva MM, Kaur K, Khokhar S, Saxena R. Comparative evaluation of teller and Cardiff acuity tests in normals and unilateral amblyopes in under-two-year-olds. Indian J Ophthalmol 2003;51:341-5.
] [Full text]
VanderVeen DK, Allred EN, Wallace DK, Leviton A, ELGAN Study Investigators. Strabismus at age 2 years in children born before 28 weeks' gestation: Antecedents and correlates. J Child Neurol 2016;31:451-60.
[Table 1], [Table 2], [Table 3], [Table 4]