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Middle East African Journal of Ophthalmology Middle East African Journal of Ophthalmology
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Year : 2019  |  Volume : 26  |  Issue : 4  |  Page : 246-249

Perioperative use of rho-kinase inhibitors has beneficial effect on corneal endothelium after phacoemulsification

1 Department of Ophthalmology, King Saud University; Cornea and Anterior Segment Consultant, King Abdulaziz University Hospital, Riyadh, Saudi Arabia
2 Department of Cornea and Anterior Segment, King Khaled Eye Specialist Hospital, Riyadh; Department of Ophthalmology, Ohud Hospital, Madinah, Saudi Arabia
3 Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh; Department of Ophthalmology, Prince Mohammed Medical City, AlJouf, Saudi Arabia

Correspondence Address:
Dr. Moustafa Magliyah
7880 Al Amir Ahmad-Madinat Al Ummal, Unit No.: 1, Al Khubar 34441-4537
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/meajo.MEAJO_27_19

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PURPOSE: Does perioperative use of Rho-Kinase (ROCK) inhibitors have beneficial effect on corneal endothelial cells after phacoemulsification? SETTING: This study was conducted at King Abdulaziz University Hospital in Riyadh. DESIGN: This was a prospective study assessing the effect of ROCK inhibitors on corneal endothelium after phacoemulsification. METHODOLOGY: Three patients have used ROCK inhibitor 1 day before and 1 week after phacoemulsification surgery, and specular microscopy and Pentacam were done preoperatively and 3 months postoperatively. RESULTS: Endothelial cell density decreased to 11.3%, 9.45%, and 4.09% in eyes with ROCK inhibitors and 23.9% in one eye without ROCK inhibitor. CONCLUSION: Perioperative ROCK inhibitor use has a possible protective effect on corneal endothelium.

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