|Year : 2020 | Volume
| Issue : 1 | Page : 4-9
Updated systematic review and clinical spectrum of peripheral exudative hemorrhagic chorioretinopathy
Abdulrahman H Badawi1, Valmore A Semidey2, Moustafa Magliyah3, Hassan Al-Dhibi2
1 King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
2 Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
3 Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh; Department of Ophthalmology, Prince Mohammed Medical City, AlJouf, Saudi Arabia
|Date of Submission||17-Mar-2020|
|Date of Acceptance||17-Apr-2020|
|Date of Web Publication||29-Apr-2020|
Dr. Abdulrahman H Badawi
King Khaled Eye Specialist Hospital, P O Box 7191, Riyadh 11462
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a rare retinal vasculopathy that might cause subretinal and/or vitreous hemorrhages. Although the primary etiology is still unknown, choroidal neovascularization is mainly involved in the pathogenesis. The main risk factors are age and systemic hypertension. Ancillary testing such as fluorescein angiography, indocyanine green angiography and ultrasonography can be of great value for diagnosing this entity and distinguishing PEHCR from other lesions as choroidal melanoma and retinal vasoproliferative tumor. Various treatments have been reported including photocoagulation, cryotherapy, intravitreal injection of anti-vascular endothelial growth factor (Anti-VEGF) and surgical intervention as pars plana vitrectomy. This review handles an up-to-date perspective regarding PEHCR.
Keywords: Antivascular endothelial growth factor, choroidal neovascularization, peripheral exudative hemorrhagic chorioretinopathy, photocoagulation, pseudomelanoma
|How to cite this article:|
Badawi AH, Semidey VA, Magliyah M, Al-Dhibi H. Updated systematic review and clinical spectrum of peripheral exudative hemorrhagic chorioretinopathy. Middle East Afr J Ophthalmol 2020;27:4-9
|How to cite this URL:|
Badawi AH, Semidey VA, Magliyah M, Al-Dhibi H. Updated systematic review and clinical spectrum of peripheral exudative hemorrhagic chorioretinopathy. Middle East Afr J Ophthalmol [serial online] 2020 [cited 2020 Jul 3];27:4-9. Available from: http://www.meajo.org/text.asp?2020/27/1/4/283496
| Introduction|| |
Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a medical term used to describe a clinical entity occurring in the peripheral retina, similar to age-related macular degeneration (ARMD). It has many different synonyms including, eccentric disciform degeneration, peripheral disciform degeneration, in addition to a peripheral hemorrhagic detachment of the retinal pigment epithelium (RPE).
In 1961, Reese and Jones were the first to describe that condition when they detected chorioretinal lesions that were similar to ARMD lesions. However, they were uncharacteristically located outside the macular region.
In 1980, Annesley et al. termed these lesions as “PEHCR.” Mashayekhi et al. reported that this condition was characterized by an extramacular hemorrhage in the subretinal or sub-RPE region, along with a peripheral exudative mass. Affected eyes can also show severe lipid exudate around the blood vessels. Although affected patients are frequently asymptomatic and have a good outcome, vitreous hemorrhage (VH) and/or subretinal hemorrhage with macular involvement can impair vision.
PEHCR is not well known due to its low frequency, difficulty to diagnose and non-standardization of its clinical entity. Moreover, PEHCR can appear to simulate choroidal melanoma (pseudomelanoma) which may lead to enucleation in some cases. Among simulating lesions, it was previously reported that PEHCR occupied the second most frequent condition after choroidal nevus in the assessment of melanoma-like lesions.
Bilateral lesions are found in 18%–37% of cases. These lesions are commonly located in the mid-peripheral or peripheral regions, especially the inferior temporal quadrant. The diagnosis of PEHCR appears to be mostly clinical, based on careful examination of the retinal fundus.,
| Risk Factors|| |
PEHCR is commonly diagnosed in older populations, similar to its counterpart, ARMD. In 2009, Shields et al. reported that the average age of cases was 80 years. Additionally, Mantel et al. recommended excluding PEHCR for patients under the age of 60.
Females usually have a high predominance in having this condition when compared to males. One study reported that 68.9% of the included cases were females. Multiple published articles have also confirmed this finding.,, This could be explained by the fact that females usually have higher life expectancy compared to males, making them more likely to reach the age when the disease becomes symptomatic.
Systemic hypertension and age have been reported to be a risk factor for both PEHCR and ARMD., Kim et al. found that hypertension was present in 75% of their included cases.
Anticoagulant intake has also been linked as a risk factor for PEHCR. It is well known that such medications increase bleeding tendencies., Vandefonteyne et al. noticed that 35.7% and 8.9% of the included cases were receiving platelet aggregation inhibitors and anticoagulants, respectively.
The reported incidence of ARMD ranges between 4.5% and 39% in cases with PEHCR, and even up to 68.9% according to Mantel et al. Although ARMD and PEHCR share some clinical features and age distribution, they are separate clinical entities as PEHCR could exist without ARMD. Additionally, Drusen, which are the hallmark of ARMD, could not be detected in PEHCR cases. Nevertheless, many ophthalmologists consider PEHCR a variant of ARMD.
About 99% of PEHCR cases were in Caucasians, a predilection for the White race has been confirmed by two other large series., PEHCR is extremely uncommon in Asians and only three isolated cases have been reported among Indians.,, Therefore, the Caucasian race may be considered an inherent risk factor for having this condition.
| Etiology|| |
Although the exact etiology remains unknown, peripheral neovascularization has been suggested. The similarities between the clinical course and fundoscopic features between PEHCR and polypoidal choroidal vasculopathy (PCV) support that hypothesis. However, neovascularization could not be demonstrated on histological examination, with only RPE rupture that was evident and through to be responsible for the retinal hemorrhage.
| Clinical Features|| |
Visual loss is the most common complaint, followed by floaters and flashes. Patients may experience metamorphopsia, scotoma, visual field defects and pain. Pain could be explained by angle closure that results from massive peripheral hemorrhage.
Shields et al. reported that most PEHCR cases were asymptomatic (about 89%); therefore, conservative treatment should be the first choice in their management.
Fundus examination and photography
Findings include VH, subretinal hemorrhage, sub-RPE hemorrhage, RPE tear, detachment, or subretinal fibrosis [Figure 1]. Moreover, lipid exudation [Figure 1] might be encountered. Some features may indicate chronicity such as RPE hyperplasia or atrophy [Figure 1], which means that there were previously undocumented lesions.,, Ultra-wide-field imaging helps in diagnosis and monitoring the course of the disease, as the pathology frequently lies anterior to the equator.
|Figure 1: Wide-field color fundus photograph showing the following: (a) Multiple areas of subretinal hemorrhages with large lesion superior nasally, peripheral laser marks and retinal pigment epithelium atrophy seen temporally as well; (b) superior temporal lesion surrounded by extensive exudation and hemorrhages, with peripheral retinal pigment epithelium changes temporally|
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| Optical Coherence Tomography (Oct)|| |
Macular OCT can give an accurate measurement of the extent of subretinal hemorrhage or fluid into the foveal region. When visual impairment is reported, it is recommended to perform an OCT [Figure 2].
|Figure 2: Posterior segment optical coherence tomography showing irregular macular thickening and mild cystoid macular edema associated with epiretinal membrane|
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| Ultrasound (Us)|| |
B-scan (US) typically reveals the presence of a dome- or plateau-shaped mass with a hollow acoustic quality. US can detect absent choroidal excavation, absent vascular pulsation, and presence of clot retraction cleft [Figure 3], which are important features seen in PEHCR.
|Figure 3: B-scan ultrasonography showing echolucent (PEHCR) lesion with the absence of choroidal excavation and orbital shadowing|
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As regards the internal reflectivity, no classic features have been determined yet, as internal reflectivity may be low, intermediate, or high (41, 36, and 19%, respectively).
Retinal vasoproliferative tumors (VPTs) tend to show medium-to-high internal reflectivity on A-scan and retinal solid lesion without choroidal excavation on B-scan.
| Fluorescein Angiography (Fa)|| |
FA may show choroidal blockage due to subretinal hemorrhage, sub-RPE hemorrhage, or RPE hyperplasia. In addition, peripheral hyperfluorescence and window defect patterns might be seen due to RPE atrophy., Although choroidal neovascularization is rarely encountered in these cases, an abnormal choroidal network can be detected.
Other non-significant findings include abnormal retinal circulation, hemi-central vein occlusion and delayed retinal filling.
| Indocyanine Green (Icg) Angiography|| |
Mantel et al. reported in two studies that ICG angiographic findings include pathological choroidal vascular polyps resembling PCV [Figure 4]., The presence of a giant RPE rip most evidenced on ICG supports the hypothesis of PEHCR being a peripheral variant of PCV as proposed.
|Figure 4:(a) Wide-field indocyanine green angiography of the right eye at 3 minutes revealed 2 areas of abnormal choroidal vascular networks (line), associated with 5 polyp-like telangiectatic lesions (arrows) at the border. (b) Indocyanine green angiography revealed 7 polyp-like lesions (arrows) in the left eye, seen only on the late frames because of partial masking by the subretinal hemorrhage. (Reproduced with permission from all authors. Mantel I, Schalenbourg A, Zografos L. Peripheral exudative hemorrhagic chorioretinopathy: Polypoidal choroidal vasculopathy and hemodynamic modifications. American journal of ophthalmology. 2012;153(5):910-22.e2.)|
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| Differential Diagnosis|| |
The most important differential diagnosis that should be considered is choroidal melanoma. To distinguish it from PEHCR, US and FA are useful tools. PEHCR and melanoma share the choroidal blockage feature due to subretinal hemorrhage in PEHCR and RPE proliferation in melanoma; choroidal melanomas show intrinsic vascularity with double circulation on FA. B-scan US shows fluid or blood in the subretinal or sub-RPE regions in PEHCR. Unlike choroidal melanoma, no choroidal excavation is seen on B-scan.
Furthermore, PEHCR is usually located at the periphery, while melanoma occurs between the macula and the equator. Melanoma involves less than one quadrant, but PEHCR usually affects more than one quadrant.
VPT can mimic PEHCR as they share some characteristic features, including the high possibility to involve the peripheral fundus, presence of VH, subretinal hemorrhages, exudation and RPE changes. The most useful modality to differentiate between both entities is FA, which shows early hyperfluorescence with late leakage at the level of the retina, commonly seen with VPT.
[Table 1] summarizes the different features among the three mentioned diseases.
|Table 1: Summarizes the different features among common differentials diagnosis|
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Other differentials include capillary hemangioma, macroaneurysm, familial exudative vitreoretinopathy, choroidal hemangioma, uveal lymphoma and choroidal metastatic tumors.,,,,
| Prognosis|| |
About 90% of PEHCR lesions resolve spontaneously, leaving an area of RPE atrophy, hyperplasia, or fibrosis. Progression to the foveal region is only detected in 11% of cases.
Kim et al. reported that there is a greater tendency for subfoveal extension in the Asian population, but the different disease natures between Asian and Caucasian populations were not well established.
Generally, PEHCR has a favorable prognosis; nevertheless, the lesion may become enlarged due to recurrent hemorrhage, leading to visual impairment.
| Treatment|| |
Multiple modalities are existing for managing PEHCR, including; laser photocoagulation, cryotherapy, photodynamic therapy (PDT), and intravitreal injection of anti-vascular endothelial growth factor (Anti-VEGF), such as Bevacizumab and Ranibizumab.
The first two modalities are always useful if peripheral vascular nets are detected. However, their efficacy in other conditions is a matter of debate. Subretinal hemorrhage could be exaggerated by laser therapy and could cause cystoid macular edema development, while cryotherapy may induce subretinal fibrosis.
PDT using Verteporfin could be helpful in the presence of subfoveal choroidal neovascularization, but choroidal atrophy may worsen after treatment.
Previous reports indicated that intravitreal Bevacizumab monthly injections resulted in good visual improvement and resolution of pre-existing subretinal hemorrhages, with stable lesion size., Similar therapeutic effects were reported using monthly Ranibizumab injections. Favorable anatomical and functional outcomes were also reported with monthly intravitreal Aflibercept injections. In a recent study, intravitreal Anti-VEGF injections were used in 51 out of 89 eyes with PEHCR and found limited visual improvements. This might be explained by the late initiation of injection.
Furthermore, the use of laser photocoagulation, in combination with Anti-VEGF, has been advocated as the treatment of choice for choroidal neovascular membrane associated with the subretinal fluid in the macular region.
Less commonly, surgical intervention may be necessary to treat massive submacular hemorrhage and/or VH., One series included five cases of dense VH, which required pars plana vitrectomy. The authors reported that optimal visual and anatomic results could be obtained with PPV to clear the hemorrhage and additional treatment may not be needed, even at long-term follow-up.
| Conclusion|| |
PEHCR is a rare retinal vasculopathy disorder presumed to be associated with aging and systemic hypertension. It is usually asymptomatic but can cause a decrease in vision. Ancillary retinal testing, including FA, ICG, and ultrasonography, can be of great value for diagnosing this entity and distinguishing PEHCR from other lesions as choroidal melanoma and retinal vasoproliferative tumor. Most lesions are usually observed. Treatment modalities include Anti-VEGF, photocoagulation, PDT, and cryotherapy. Surgical intervention is reserved for unresolved VH and/or subretinal hemorrhage involving the macula as these presentations are the most prevalent causes of a decline in vision. Subsequent follow-up visits are recommended in asymptomatic patients for possible complications, which might affect sight.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Shields JA, Mashayekhi A, Ra S, Shields CL. Pseudomelanomas of the posterior uveal tract: The 2006 Taylor R. Smith Lecture. Retina 2005;25:767-71.
Reese AB, Jones IS. Hematomas under the retinal pigment epithelium. Trans Am Ophthalmol Soc 1961;59:43-79.
Annesley WH Jr. Peripheral exudative hemorrhagic chorioretinopathy. Trans Am Ophthalmol Soc 1980;78:321-64.
Mashayekhi A, Shields CL, Shields JA. Peripheral exudative hemorrhagic chorioretinopathy: A variant of polypoidal choroidal vasculopathy? J Ophthalmic Vis Res 2013;8:264-7. [Full text]
Ghahvehchian H, Riazi H, Mirghorbani M. Peripheral exudative hemorrhagic chorioretinopathy, a melanoma mimic. ARC J Ophthalmol 2019;4:11-2.
Goel N. Vitreous hemorrhage as the presenting feature of peripheral exudative hemorrhagic chorioretinopathy in Indian eyes. Indian J Ophthalmol 2019;67:419-23.
] [Full text]
Shields CL, Salazar PF, Mashayekhi A, Shields JA. Peripheral exudative hemorrhagic chorioretinopathy simulating choroidal melanoma in 173 eyes. Ophthalmology 2009;116:529-35.
Shields JA, Shields CL. Nonneoplastic conditions that can simulate posterior uveal melanoma and other intraocular neoplasms. In: Shields JA, Shields CL, editors. Intraocular Tumors: An Atlas and Textbook. China: Wolters Kluwer; 2016. p. 557-630.
Huang J, Gajewski A, Cesaro T, Messina C, Mega JV Jr., Sellechio J. Peripheral exudative hemorrhagic chorioretinopathy in patients with nonexudative age-related macular degeneration. Fed Pract 2017;34:20-2.
Vandefonteyne S, Caujolle J-P, Rosier L, Conrath J, Quentel G, Tadayoni R, et al
. Diagnosis and treatment of peripheral exudative hemorrhagic chorioretinopathy. British Journal of Ophthalmology 2019;0:1-5.
Khurshid G. Peripheral exudative hemorrhagic chorioretinopathy. JAMA Ophthalmol 2017;135:e165491.
Mantel I, Uffer S, Zografos L. Peripheral exudative hemorrhagic chorioretinopathy: A clinical, angiographic, and histologic study. Am J Ophthalmol 2009;148:932-80.
Bardenstein DS, Char DH, Irvine AR, Stone RD. Extramacular disciform lesions simulating uveal tumors. Ophthalmology 1992;99:944-51.
Vine AK, Johnson MW. Peripheral choroidal neovascularization. Eur J Ophthalmol 1996;6:44-9.
Kim YT, Kang SW, Lee JH, Chung SE. Peripheral exudative hemorrhagic chorioretinopathy in Korean patients. Jpn J Ophthalmol 2010;54:227-31.
Seibel I, Hager A, Duncker T, Riechardt AI, Nürnberg D, Klein JP, et al
. Anti-VEGF therapy in symptomatic peripheral exudative hemorrhagic chorioretinopathy (PEHCR) involving the macula. Graefes Arch Clin Exp Ophthalmol 2016;254:653-9.
Reese AB, Jones IS. Hematomas under the retinal pigment epithelium. Am J Ophthalmol 1962;53:897-910.
Mantel I, Schalenbourg A, Zografos L. Peripheral exudative hemorrhagic chorioretinopathy: Polypoidal choroidal vasculopathy and hemodynamic modifications. Am J Ophthalmol 2012;153:910-2200.
Rishi P, Das A, Sarate P, Rishi E. Management of peripheral polypoidal choroidal vasculopathy with intravitreal bevacizumab and indocyanine green angiography-guided laser photocoagulation. Indian J Ophthalmol 2012;60:60-3.
] [Full text]
Kumar V, Janakiraman D, Chandra P, Kumar A. Ultra-wide field imaging in peripheral exudative hemorrhagic chorioretinopathy (PEHCR). BMJ Case Rep 2015;2015:bcr2015213628.
Takkar B, Roy S, Sodhi PK, Azad S, Bajwa GS. Peripheral choroidal neovascular membrane in a case of peripheral exudative hemorrhagic chorioretinopathy managed with combination therapy. Int Ophthalmol 2017;37:429-31.
Takayama K, Enoki T, Kojima T, Ishikawa S, Takeuchi M. Treatment of peripheral exudative hemorrhagic chorioretinopathy by intravitreal injections of ranibizumab. Clin Ophthalmol 2012;6:865-9.
Bloome MA, Ruiz RS. Massive spontaneous subretinal hemorrhage. Am J Ophthalmol 1978;86:630-7.
Alforja MS, Sabater N, Giralt J, Adán A, Pelegrín L, Casaroli-Marano R. Intravitreal bevacizumab injection for peripheral exudative hemorrhagic chorioretinopathy. Jpn J Ophthalmol 2011;55:425-7.
Rennie IG. Retinal vasoproliferative tumours. Eye (Lond) 2010;24:468-71.
Bec P, Secheyron P, Arne JL, Aubry JP. Renewed peripheral sub-retinal vascularization and its pathological consequences. J Fr Ophtalmol 1979;2:329-36.
Kumar V, Tewari R. Giant retinal pigment epithelium rip in a patient with peripheral exudative hemorrhagic chorioretinopathy. Indian J Ophthalmol 2019;67:1164-5.
] [Full text]
Alsakran WA, Alshamrani AA, Alzahrani YA. Variable presentations of peripheral exudative hemorrhagic chorioretinopathy. Middle East Afr J Ophthalmol 2019;26:253-6. [Full text]
Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, et al
. Polypoidal choroidal vasculopathy: Natural history. Am J Ophthalmol 2002;133:639-48.
Collaer N, James C. Peripheral exudative and hemorrhagic chorio-retinopathy…the peripheral form of age-related macular degeneration? Bull Soc Belge Ophthalmol 2007;305:23-6.
Gonzales JA, Kapoor KG, Gibran SK. Peripheral exudative hemorrhagic chorioretinopathy: A clinical, angiographic, and histologic study. Am J Ophthalmol 2010;149:1013-4.
Sax J, Karpa M, Reddie I. Response to intravitreal aflibercept in a patient with peripheral exudative hemorrhagic chorioretinopathy. Retin Cases Brief Rep 2018. p. 1-3.
Goldman DR, Freund KB, McCannel CA, Sarraf D. Peripheral polypoidal choroidal vasculopathy as a cause of peripheral exudative hemorrhagic chorioretinopathy: A report of 10 eyes. Retina 2013;33:48-55.
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