Outcomes of combination therapy using aflibercept and dexamethasone intravitreal implant versus dexamethasone monotherapy for macular edema secondary to retinal vein occlusion

Walid Harb; Georgio Chidiac; Georges Harb

doi:10.4103/meajo.MEAJO_297_19

Middle East African Journal of Ophthalmology

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ORIGINAL ARTICLE

Year : 2021 | Volume : 28 | Issue : 1 | Page : 18-22

Outcomes of combination therapy using aflibercept and dexamethasone intravitreal implant versus dexamethasone monotherapy for macular edema secondary to retinal vein occlusion

Walid Harb¹, Georgio Chidiac², Georges Harb³
¹ Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh; Department of Ophthalmology, University Hospital Center – Notre Dame des Secours, Byblos; Department of Ophthalmology, Clinique du Levant; Faculty of Medicine, Lebanese University, Beirut, Lebanon
² Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh; Department of Dermatology, University Hospital Center – Notre Dame des Secours, Byblos, Lebanon
³ Department of Ophthalmology, Clinique du Levant; Faculty of Medicine, Lebanese University, Beirut; Holy Family University, Batroun, Lebanon

Correspondence Address:
Dr. Georges Harb
Department of Ophthalmology, Clinique du Levant, Beirut, Lebanon. Faculty of Medicine, Lebanese University, Beirut, Lebanon. Holy Family University, Batroun
Lebanon

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/meajo.MEAJO_297_19

PURPOSE: The purpose of this study was to evaluate the efficacy of the combination therapy of intravitreal aflibercept 2 mg (Eylea^®) and a sustained-release dexamethasone 0.7 mg intravitreal implant (Ozurdex^®) versus dexamethasone alone in providing better visual acuity in eyes with macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: Seventy-four eyes of 74 patients with treatment-naïve ME secondary to RVO were included in this prospective nonrandomized case series and were studied over a 12-month follow-up period. Patients in the dexamethasone monotherapy group were treated with an initial Ozurdex^® injection while patients in the combination therapy group were treated with an Eylea^® injection followed 2 weeks later by an Ozurdex^® injection. The treatment was repeated as needed. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure were evaluated periodically. The primary outcome measure was the BCVA. The secondary outcome measures included CMT, number of retreatments, and safety parameters. RESULTS: At 1 year, the primary endpoint was met. Patients receiving combined therapy had better mean visual acuity changes from baseline compared to those receiving monotherapy (0.369 ± 0.221 logarithm of the minimum angle of resolution [logMAR] vs. 0.218 ± 0.171 logMAR; P = 0.002). The secondary endpoints were not met since there were no significant differences in mean reductions in CMT (272.67 ± 82.35 vs. 248.11 ± 159.73; P = 0.412) and the mean number of retreatments was similar in the two groups (1.75 ± 1.13 vs. 1.42 ± 0.64; P = 0.126). CONCLUSION: Aflibercept with dexamethasone implants achieved better visual outcomes compared to dexamethasone monotherapy with no significant differences in intravitreal retreatment rates at the 1^st year in eyes with ME secondary to RVO.

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