Middle East African Journal of Ophthalmology

: 2010  |  Volume : 17  |  Issue : 3  |  Page : 268--269

Small choroidal melanoma with monosomy 3

Fariba Ghassemi, Carol L Shields, Miguel A Materin, Jerry A Shields 
 Department of Ocular Oncology Service, Wills Eye Institute, Philadelphia, PA, USA

Correspondence Address:
Carol L Shields
Ocular Oncology Service, Suite 1440, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107

Purpose: To report a patient with small juxtapapillary choroidal melanoma with chromosome 3 monosomy treated with I 125 plaque and transpupillary thermotherapy (TTT). A 64-year-old Caucasian male presented with painless blurred vision of the left eye. Ocular examination disclosed a small juxtapapillary choroidal melanocytic tumor with overlying subretinal fluid and orange pigment. Ultrasound showed an elevated choroidal mass of 2 mm thickness with low reflectivity on A-scan and hollowness on B scan, consistent with a small choroidal melanoma. The patient was treated with plaque I 125 radiotherapy combined with one session of TTT. Genetic testing of the tumor cells obtained by fine needle aspiration biopsy showed chromosome 3 monosomy. At 1 year after treatment, the tumor was regressed with resolution of subretinal fluid and 20/40 visual acuity. A small choroidal melanoma can manifest monosomy of chromosome 3, a known predictive factor for the development of systemic metastasis.

How to cite this article:
Ghassemi F, Shields CL, Materin MA, Shields JA. Small choroidal melanoma with monosomy 3.Middle East Afr J Ophthalmol 2010;17:268-269

How to cite this URL:
Ghassemi F, Shields CL, Materin MA, Shields JA. Small choroidal melanoma with monosomy 3. Middle East Afr J Ophthalmol [serial online] 2010 [cited 2019 Oct 15 ];17:268-269
Available from: http://www.meajo.org/article.asp?issn=0974-9233;year=2010;volume=17;issue=3;spage=268;epage=269;aulast=Ghassemi;type=0