Year : 2015 | Volume
: 22 | Issue : 1 | Page : 103--107
Regression rate of posterior uveal melanomas following iodine-125 plaque radiotherapy
Hakan Demirci1, Fiorella Saponara1, Adam Khan1, Leslie M Niziol1, Choonik Lee2, James A Hayman2, Grant Comer1, David C Musch3
1 Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, Michigan, USA
2 Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
3 Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, Michigan; Department of Epidemiology, School of Public Health, Michigan, USA
Aim: To characterize the regression rate of posterior uveal melanoma following radioactive iodine-125 (I-125) plaque.
Materials and Methods: We retrospectively analyzed 95 patients with posterior uveal melanoma who were treated with only radioactive I-125 plaque and had more than 3 years follow-up. All patients were treated with plaque radiotherapy using tumor dose of 85 Gy at the tumor apex, following COMS protocol. Regression rate was assessed with standardized A-scan ultrasonography. Associations with tumor regression were evaluated by means of mixed linear regression modeling.
Results: Mean decrease in the tumor thickness (% original thickness) at 12, 24, and 36 months after radiotherapy for melanomas <3 mm in thickness was 29%, 38%, and 45%, for melanoma 3-8 mm in thickness was 32%, 44%, and 59%, and for melanoma more than 8 mm in thickness was 52%, 62%, and 68%, respectively. With a doubling of follow-up time (0.5-1 year, or 1-2 years of follow-up from treatment), tumors <3 mm in thickness at treatment showed a 0.5 mm decrease in tumor thickness, whereas melanomas 3-8 mm showed a 1 mm decrease, and melanomas >8 mm showed a 1.7 mm decrease. Uveal melanomas that developed systemic metastasis showed an additional 0.4 mm decrease with a doubling of follow-up time from treatment, compared with those that did not develop metastasis (P = 0.050).
Conclusions: Posterior uveal melanomas with higher initial thickness show steeper and more reduction in tumor thickness following radioactive I-125 plaque. After the initial phases, the regression curve became similar for tumors with different thicknesses.
W.K. Kellogg Eye Center, 1000 Wall Street, Ann Arbor, Michigan, 48105
|How to cite this article:|
Demirci H, Saponara F, Khan A, Niziol LM, Lee C, Hayman JA, Comer G, Musch DC. Regression rate of posterior uveal melanomas following iodine-125 plaque radiotherapy.Middle East Afr J Ophthalmol 2015;22:103-107
|How to cite this URL:|
Demirci H, Saponara F, Khan A, Niziol LM, Lee C, Hayman JA, Comer G, Musch DC. Regression rate of posterior uveal melanomas following iodine-125 plaque radiotherapy. Middle East Afr J Ophthalmol [serial online] 2015 [cited 2022 Oct 6 ];22:103-107
Available from: http://www.meajo.org/article.asp?issn=0974-9233;year=2015;volume=22;issue=1;spage=103;epage=107;aulast=Demirci;type=0