Year : 2016 | Volume
: 23 | Issue : 2 | Page : 201--207
«DQ»Combined occlusion and atropine therapy«DQ» versus «DQ»Augmented part-time patching«DQ» in children with refractory/residual amblyopia: A pilot study
Virender Sachdeva1, Vaibhev Mittal1, Varun Gupta1, Rekha Gunturu1, Ramesh Kekunnaya2, Anjali Chandrasekharan2, Preeti Patil Chabblani2, Harsha L Rao3
1 Department of Pediatric Ophthalmology, Strabismus and Neuro ophthalmology, Nimmagada Prasad Children's Eye Care Centre, L. V. Prasad Eye Institute, Visakhapatnam, India
2 Department of Pediatric Ophthalmology, Strabismus and Neuro ophthalmology, Jasti V Ramanamma Children's Eye Care Centre, L. V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
3 Centre for Clinical Epidemiology and Biostatistics, L. V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
Purpose: To compare the efficacy of «DQ»combined occlusion and atropine therapy (COAT)«DQ» and «DQ»augmented part-time patching«DQ» for the treatment of unilateral refractory/residual amblyopia.
Methodology: This retrospective study evaluated children between 4 and 11 years with refractory/residual amblyopia who were treated with either additional atropine (COAT group) or increased hours of patching (augmented group). Data were collected on improvement in best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution [logMAR] units) at each follow-up visit.
Results: There were 19 children in the COAT group and 17 children in the augmented group. The baseline BCVA of the amblyopic eye was 0.79 ± 0.36 logMAR in the COAT group and 0.72 ± 0.26 logMAR in augmented group. Children were statistically significantly younger in the COAT group (6.4 ± 2.2 years) compared to the augmented group (8.6 ± 3.3 years, P = 0.02). The mean duration of follow-up was statistically significantly longer in the augmented group (20.2 COAT group; 13.9 months augmented group) (P = 0.03). Compliance was similar in both groups. LogMAR BCVA (adjusted for difference in age and baseline BCVA) was statistically significantly better in the COAT group (0.56 ± 0.04) compared to the augmented group (0.80 ± 0.04) at 3 months (P = 0.000); 6 months (COAT group, 0.50 ± 0.04 vs. augmented group, 0.74 ± 0.04; P = 0.04) and at 1 year (COAT group, 0.42 ± 0.04 vs. augmented group, 0.67 ± 0.04, P = 0.000). There was statistically significantly greater improvement in logMAR BCVA at 6 months in COAT group (0.26 ± 0.15) compared to the augmented group (0.02 ± 0.14), (P = 0.0002). Age, gender, pretreatment BCVA, duration of follow-up, or compliance to patching did not affect improvement in BCVA.
Conclusions: COAT may result in greater improvement in BCVA than augmented part-time patching in children with unilateral residual/refractory amblyopia.
|How to cite this article:|
Sachdeva V, Mittal V, Gupta V, Gunturu R, Kekunnaya R, Chandrasekharan A, Chabblani PP, Rao HL. "Combined occlusion and atropine therapy" versus "Augmented part-time patching" in children with refractory/residual amblyopia: A pilot study.Middle East Afr J Ophthalmol 2016;23:201-207
|How to cite this URL:|
Sachdeva V, Mittal V, Gupta V, Gunturu R, Kekunnaya R, Chandrasekharan A, Chabblani PP, Rao HL. "Combined occlusion and atropine therapy" versus "Augmented part-time patching" in children with refractory/residual amblyopia: A pilot study. Middle East Afr J Ophthalmol [serial online] 2016 [cited 2020 Sep 28 ];23:201-207
Available from: http://www.meajo.org/article.asp?issn=0974-9233;year=2016;volume=23;issue=2;spage=201;epage=207;aulast=Sachdeva;type=0